Magdalena Zernicka-Goetz Group
Mammalian Embryo and Stem Cell Groups | Cambridge and Caltech
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Self-organization of stem cells into embryos: A window on early mammalian development. Science (2019). Celebrating women in science: a new profile of the work in our lab examines our attempts to solve the mysteries of the embryo. Written by Marissa Fessenden. Illustration by Zoe Van Dijk. Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature (2017). Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nat Cell Biol. (2018). Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature. (2017). Self-organization of stem cells into embryos: A window on early mammalian development. Science (2019). Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro. Dev Cell. (2021).
Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation. Nat Commun (2019). Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid. Dev Cell (2019).
Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism. Nat Commun (2020). Developmental clock and mechanism of de novo polarization of the mouse embryo. Science (2020). Embryo Size Regulates the Timing and Mechanism of Pluripotent Tissue Morphogenesis. Stem Cell Reports (2021). Trophectoderm mechanics direct epiblast shape upon embryo implantation. Cell Rep. (2021). Unifying synthetic embryology. Dev Biol (2021).
Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation. Nat Cell Biol (2018). In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cell. Nat Protoc. (2018). Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition. Cell Rep. (2021). CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development. Cell (2018). Deconstructing and reconstructing the mouse and human early embryo. Nat Cell Biol (2018). Basement membrane remodeling regulates mouse embryogenesis. Nature (2020). Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo. Nat Commun. (2017). Principles of self organization of the mammalian embryo. Cell. (2020). A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre. Nat Commun.
Meet the Lab
PhD Student, Caltech Antonia Weberling
PhD Student, Cambridge Adiyant Lamba
PhD Student, Cambridge Bailey Weatherbee
PhD Student, Cambridge Carlos Ganter
Post-doc, Cambridge Dong-Yuan Chen
Post-doc, Caltech Clare Reynell
Lab Manager, Caltech Estefania Sanchez-Vasquez
PhD Student, Caltech Hannah Greenfeld
Post-doc, Caltech Kirsty Mackinlay
PhD Student, Cambridge Kasey Y.C. Lau
PhD Student, Cambridge Maciej Meglicki
Lab Manager, Cambridge Magdalena Zernicka-Goetz
Principle Investigator Melissa Truong
Post-doc, Caltech Gianluca Amadei
Post-doc, Cambridge Charlotte Handford
PhD Student, Cambridge Joey Kalappurakkal
Post-doc, Cambridge Min Bao
Post-doc, Caltech Lauren Hulme
Lab Technician, Cambridge Lisa-Iwatmoto Stohl
PhD Student, Cambridge
The Dance of Life
The Dance of Life will take you inside the incredible world of life just as it begins. It reveals the wonder of the earliest and most profound moments of early life; how we become human. Through Magda’s trailblazing research as a professor at Cambridge, you’ll learn how early life starts to take shape and discover the true beauty of life’s beginnings
– Penguin Random House LLC.
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