Publications from our lab

Molè MA, Coorens THH, Shahbazi MN, Weberling A, Weatherbee BAT, Gantner CW, Sancho-Serra C, Richardson L, Drinkwater A, Syed N, Engley S, Snell P, Christie L, Elder K, Campbell A, Fishel S, Behjati S, Vento-Tormo R and Zernicka-Goetz M. (2021). A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre. Nat Commun. 12(1):3679. doi: 10.1038/s41467-021-23758-w. PMID: 34140473. Click to see.

Guo J, Wang P, Sozen B, Qiu H, Zhu Y, Zhang X, Ming J, Zernicka-Goetz M and Na J. (2021). Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro. Stem Cell Reports. 16(5):1331-1346. doi: 10.1016/j.stemcr.2021.03.018. PMID: 33891867. Click to see.

Shi J*, Zhang Y*, Tan D*, Zhang X*, Yan M*, Zhang Y* Franklin R*, Shahbazi M, Mackinlay K, Liu S, Kuhle B, James ER, Zhang L, Qu Y, Zhai Q, Zhao W, Zhao L, Zhou C, Gu W, Murn J, Guo J, Carrell DT, Wang Y, Chen X, Cairns BR, Yang XL, Schimmel P, Zernicka-Goetz M, Cheloufi S, Zhang Y, Zhou T and Chen Q. (2021). PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. Nat Cell Biol. 23(4):424-436. doi: 10.1038/s41556-021-00652-7. PMID: 33820973. Click to see.

Cornwall-Scoones J and Zernicka-Goetz M. (2021). Unifying synthetic embryology. Dev Biol. S0012-1606(21)00069-5. doi: 10.1016/j.ydbio.2021.03.007. PMID: 33753081. Click to see.

Molè MA, Weberling A, Fässler R, Campbell A, Fishel S and Zernicka-Goetz M. (2021). Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition. Cell Rep. 34(10):108834. doi: 10.1016/j.celrep.2021.108834. PMID: 33691117. Click to see.

Weberling A and Zernicka-Goetz M. (2021). Trophectoderm mechanics direct epiblast shape upon embryo implantation. Cell Rep. 34(3):108655. doi: 10.1016/j.celrep.2020.108655. PMID: 33472064. Click to see.

Amadei G, Lau KYC, De Jonghe J, Gantner CW, Sozen B, Chan C, Zhu M, Kyprianou C, Hollfelder F and Zernicka-Goetz M. (2021). Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro. Dev Cell. 56(3):366-382.e9. doi: 10.1016/j.devcel.2020.12.004. PMID: 33378662. Click to see.

Weatherbee BAT, Cui T and Zernicka-Goetz M. (2020). Modeling human embryo development with embryonic and extra-embryonic stem cells. Dev Biol. S0012-1606(20)30319-5. doi: 10.1016/j.ydbio.2020.12.010. PMID: 33333069. Click to see.

Sozen B, Cornwall-Scoones J and Zernicka-Goetz M. (2020). The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking. Dev Biol. S0012-1606(20)30315-8. doi: 10.1016/j.ydbio.2020.12.005. PMID: 33333067. Click to see.

Zhu M, Cornwall-Scoones J, Wang P, Handford CE, Na J, Thomson M and Zernicka-Goetz M. (2020). Developmental clock and mechanism of de novo polarization of the mouse embryo. Science. 370(6522):eabd2703. doi: 10.1126/science.abd2703. PMID: 33303584. Click to see.

Sozen B, Demir N and Zernicka-Goetz M. (2021). BMP signalling is required for extra-embryonic ectoderm development during pre-to-post-implantation transition of the mouse embryo. Dev Biol. 470:84-94. doi: 10.1016/j.ydbio.2020.11.005. PMID: 33217407. Click to see.

Orietti LC, Rosa VS, Antonica F, Kyprianou C, Mansfield W, Marques-Souza H, Shahbazi MN and Zernicka-Goetz M. (2020). Embryo Size Regulates the Timing and Mechanism of Pluripotent Tissue Morphogenesis. Stem Cell Reports. S2213-6711(20)30379-9. doi: 10.1016/j.stemcr.2020.09.004. PMID: 33035465.ffb400. Click to see.

Lynch CJ, Bernad R, Martínez-Val A, Shahbazi MN, Nóbrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Ginés L, Alcazar N, Graña-Castro O, Gómez-Lopez G, Aksoy I, Muñoz-Martín M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Muñoz J, Zernicka-Goetz M and Serrano M. (2020). Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat Cell Biol. 22(10):1223-1238. doi: 10.1038/s41556-020-0573-1. PMID: 32989249. Click to see.

Cornwall-Scoones J and Zernicka-Goetz M. (2020). Starting life in space. Natl Sci Rev. 7(9):1447-1448. doi: 10.1093/nsr/nwaa102. PMID: 32983580. Click to see.

Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT Jr, Seli E and Zernicka-Goetz M. (2020). Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 11(1):3987. doi: 10.1038/s41467-020-17764-7. PMID: 32778678. Click to see.

Weatherbee BAT, Glover DM and Zernicka-Goetz M. (2020). Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester. Open Biol.10(8):200162. doi: 10.1098/rsob.200162. PMID: 32750256. Click to see.

Singla S, Iwamoto-Stohl LK, Zhu M and Zernicka-Goetz M. (2020). Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism. Nat Commun. 11(1):2958. doi: 10.1038/s41467-020-16796-3. PMID: 32528010. Click to see.

Kyprianou C*, Christodoulou N*, Hamilton RS, Nahaboo W, Boomgaard DS, Amadei G, Migeotte I and Zernicka-Goetz M. (2020). Basement membrane remodelling regulates mouse embryogenesis. Nature. 582(7811):253-258. doi: 10.1038/s41586-020-2264-2. PMID: 32523119. Click to see.

Zhu M and Zernicka-Goetz M. (2020). Living a Sweet Life: Glucose Instructs Cell Fate in the Mouse Embryo. Dev Cell. 53(1):1-2. doi: 10.1016/j.devcel.2020.03.012. PMID: 32259489. Click to see.

Sozen B, Cox AL, De Jonghe J, Bao M, Hollfelder F, Glover DM and Zernicka-Goetz M. (2019). Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid. Dev Cell. 51(6):698-712.e8. doi: 10.1016/j.devcel.2019.11.014. PMID: 31846649. Click to see.

Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA and Huch M. (2019). Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration. Nat Cell Biol. 21(11):1321-1333. doi: 10.1038/s41556-019-0402-6. PMID: 31685987. Click to see.

Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M and Zhuang X. (2019). Voices in methods development. Nat Methods. 16(10):945-951. doi: 10.1038/s41592-019-0585-6. PMID: 31562479. Click to see.

Christodoulou N, Weberling A, Strathdee D, Anderson KI, Timpson P and Zernicka-Goetz M. (2019). Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation. Nat Commun. 10(1):3557. doi: 10.1038/s41467-019-11482-5. PMID: 31391456. Click to see.

Shahbazi MN*, Siggia ED* and Zernicka-Goetz M*. (2019). Self-organization of stem cells into embryos: A window on early mammalian development. Science. 364(6444):948-951. doi: 10.1126/science.aax0164. PMID: 31171690. Click to see.

Antonica F, Orietti LC, Mort RL and Zernicka-Goetz M. (2019). Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. Dev Biol. 450(2):132-140. doi: 10.1016/j.ydbio.2019.03.016. PMID: 30940540. Click to see.

Hupalowska A, Jedrusik A, Zhu M, Bedford MT, Glover DM and Zernicka-Goetz M. (2018). CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development. Cell. 175(7):1902-1916.e13. doi: 10.1016/j.cell.2018.11.027. PMID: 30550788. Click to see.

Rivron N, Pera M, Rossant J, Martinez Arias A, Zernicka-Goetz M, Fu J, van den Brink S, Bredenoord A, Dondorp W, de Wert G, Hyun I, Munsie M and Isasi R. (2018). Debate ethics of embryo models from stem cells. Nature. 564(7735):183-185. doi: 10.1038/d41586-018-07663-9. PMID: 30542177. Click to see.

Christodoulou N, Kyprianou C, Weberling A, Wang R, Cui G, Peng G, Jing N and Zernicka-Goetz M. (2018). Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation. Nat Cell Biol. 20(11):1278-1289. doi: 10.1038/s41556-018-0211-3. PMID: 30323188. Click to see.

McCann BJ, Cox A, Gammage PA, Stewart JB, Zernicka-Goetz M and Minczuk M. (2018). Delivery of mtZFNs into Early Mouse Embryos. Methods Mol Biol. 1867:215-228. doi: 10.1007/978-1-4939-8799-3_16. PMID: 30155826. Click to see.

Sozen B*, Amadei G*, Cox A, Wang R, Na E, Czukiewska S, Chappell L, Voet T, Michel G, Jing N, Glover DM and Zernicka-Goetz M. (2018). Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nat Cell Biol. 20(8):979-989. doi: 10.1038/s41556-018-0147-7. PMID: 30038254. Click to see.

Harrison SE, Sozen B and Zernicka-Goetz M. (2018). In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells. Nat Protoc. 13(7):1586-1602. doi: 10.1038/s41596-018-0005-x. PMID: 29988106. Click to see.

Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, Vlahov N, Grawenda A, Haider S, Chauhan J, Buti L, Kanapin A, Lu X, Buffa F, Dianov G, von Kriegsheim A, Matallanas D, Samsonova A, Zernicka-Goetz M and O’Neill E. (2018). RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Nat Commun. 9(1):424. doi: 10.1038/s41467-017-02786-5. PMID: 29382819. Click to see.

Shahbazi MN, Scialdone A, Skorupska N, Weberling A, Recher G, Zhu M, Jedrusik A, Devito LG, Noli L, Macaulay IC, Buecker C, Khalaf Y, Ilic D, Voet T, Marioni JC and Zernicka-Goetz M. (2017). Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature. 552(7684):239-243. doi: 10.1038/nature24675. PMID: 29186120. Click to see.

Strauss B, Harrison A, Coelho PA, Yata K, Zernicka-Goetz M and Pines J. (2017). Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis. J Cell Biol. 217(1):179-193. doi: 10.1083/jcb.201612147. PMID: 29074707. Click to see.

Zhu M, Leung CY, Shahbazi MN and Zernicka-Goetz M. (2017). Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo. Nat Commun. 8(1):921. doi: 10.1038/s41467-017-00977-8. PMID: 29030553. Click to see.

Bury L, Coelho PA, Simeone A, Ferries S, Eyers CE, Eyers PA, Zernicka-Goetz M and Glover DM. (2017). Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes. J Cell Biol. 216(11):3571-3590. doi: 10.1083/jcb.201606077. PMID: 28972102. Click to see.

Ajduk A, Strauss B, Pines J and Zernicka-Goetz M. (2017). Delayed APC/C activation extends the first mitosis of mouse embryos. Sci Rep. 7(1):9682. doi: 10.1038/s41598-017-09526-1. PMID: 28851945. Click to see.

Goolam M and Zernicka-Goetz M. (2017). The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo. Development. 144(8):1450-1461. doi: 10.1242/dev.144139. PMID: 28289135. Click to see.

Harrison SE, Sozen B, Christodoulou N, Kyprianou C and Zernicka-Goetz M. (2017). Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science. 356(6334):eaal1810. doi: 10.1126/science.aal1810. PMID: 28254784. Click to see.

Shahbazi MN*, Jedrusik A*, Vuoristo S*, Recher G, Hupalowska A, Bolton V, Fogarty NNM, Campbell A, Devito L, Ilic D, Khalaf Y, Niakan KK, Fishel S and Zernicka-Goetz M. (2016). Self-organization of the human embryo in the absence of maternal tissues. Nat Cell Biol. 18(6):700-708. doi: 10.1038/ncb3347. PMID: 27144686. Click to see.

Deglincerti A, Croft GF, Pietila LN, Zernicka-Goetz M, Siggia ED and Brivanlou AH. (2016). Self-organization of the in vitro attached human embryo. Nature. 533(7602):251-4. doi: 10.1038/nature17948. PMID: 27144363. Click to see.

Leung CY, Zhu M and Zernicka-Goetz M. (2016). Polarity in Cell-Fate Acquisition in the Early Mouse Embryo. Curr Top Dev Biol. 120:203-34. doi: 10.1016/bs.ctdb.2016.04.008. PMID: 27475853. Click to see.

Bolton H, Graham SJL, Van der Aa N, Kumar P, Theunis K, Fernandez Gallardo E, Voet T and Zrnicka-Goetz M. (2016). Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential. Nat Commun. 7:11165. doi: 10.1038/ncomms11165. PMID: 27021558. Click to see.

Goolam M, Scialdone A, Graham SJL, Macaulay IC, Jedrusik A, Hupalowska A, Voet T, Marioni JC and Zernicka-Goetz M. (2016). Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos. Cell. 165(1):61-74. doi: 10.1016/j.cell.2016.01.047. PMID: 27015307. Click to see.

Panamarova M, Cox A, Wicher KB, Butler R, Bulgakova N, Jeon S, Rosen B, Seong RH, Skarnes W, Crabtree G and Zernicka-Goetz M. (2016). The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. Development. 143(8):1271-83. doi: 10.1242/dev.131961. PMID: 26952987. Click to see.

Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz M and Glover DM. (2015). Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse. Open Biol. 5(12):150209. doi: 10.1098/rsob.150209. PMID: 26701933. Click to see.

Ajduk A and Zernicka-Goetz M. (2015). Polarity and cell division orientation in the cleavage embryo: from worm to human. Mol Hum Reprod. 22(10):691-703. doi: 10.1093/molehr/gav068. PMID: 26660321. Click to see.

Bedzhov I, Bialecka M, Zielinska A, Kosalka J, Antonica F, Thompson AJ, Franze K and Zernicka-Goetz M. (2015). Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo. Cell Res. 25(12):1368-71. doi: 10.1038/cr.2015.104. PMID: 26337800. Click to see.

Macaulay IC, Haerty W, Kumar P, Li YI, Hu TX, Teng MJ, Goolam M, Saurat N, Coupland P, Shirley LM, Smith M, Van der Aa N, Banerjee R, Ellis PD, Quail MA, Swerdlow HP, Zernicka-Goetz M, Livesey FJ, Ponting CP and Voet T. (2015). G&T-seq: parallel sequencing of single-cell genomes and transcriptomes. Nat Methods.12(6):519-22. doi: 10.1038/nmeth.3370. PMID: 25915121. Click to see.

Bedzhov I and Zernicka-Goetz M. (2015). Cell death and morphogenesis during early mouse development: are they interconnected? Bioessays. 37(4):372-8. doi: 10.1002/bies.201400147. PMID: 25640415. Click to see.

Graham SJ, Wicher KB, Jedrusik A, Guo G, Herath W, Robson P and Zernicka-Goetz M. (2014). BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryoNat Commun. 5:5667. doi: 10.1038/ncomms6667. PMID: 25514175. Click to see.

Jedrusik A, Cox A, Wicher KB, Glover DM and Zernicka-Goetz M. (2014). Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition. Dev Biol. 398(2):147-52. doi: 10.1016/j.ydbio.2014.12.004. PMID: 25512302. Click to see.

Bedzhov I, Leung CY, Bialecka M and Zernicka-Goetz M. (2014). In vitro culture of mouse blastocysts beyond the implantation stages. Nat Protoc. 9(12):2732-9. doi: 10.1038/nprot.2014.186. PMID: 25356584. Click to see.

Ajduk A, Biswas Shivhare S and Zernicka-Goetz M. (2014). The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo. Dev Biol. 392(2):133-40. doi: 10.1016/j.ydbio.2014.05.009. PMID: 24855000. Click to see.

Bedzhov I and Zernicka-Goetz M. (2014). Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation. Cell. 156(5):1032-44. doi: 10.1016/j.cell.2014.01.023. PMID: 24529478. Click to see.

Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB and Kouzarides T. (2014). Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature. 507(7490):104-8. doi:10.1038/nature12942. PMID: 24463520. Click to see.

Coelho PA, Bury L, Sharif B, Riparbelli MG, Fu J, Callaini G, Glover DM and Zernicka-Goetz M. (2013). Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles. Dev Cell. 27(5):586-97. doi:10.1016/j.devcel.2013.09.029. PMID: 24268700. Click to see.

Morris SA, Graham SJ, Jedrusik A and Zernicka-Goetz M. (2013). The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos. Open Biol. 3(11):130104. doi: 10.1098/rsob.130104. PMID: 24258274. Click to see.

Leung CY and Zernicka-Goetz M. (2013). Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms. Nat Commun. 4:2251. doi: 10.1038/ncomms3251. PMID: 23903990. Click to see.

Skamagki M, Wicher KB, Jedrusik A, Ganguly S and Zernicka-Goetz M. (2013). Asymmetric localization of Cdx2 mRNA during the first cell-fate decision in early mouse development. Cell Rep. 3(2):442-57. doi: 10.1016/j.celrep.2013.01.006. PMID: 23375373. Click to see.

Zernicka-Goetz M. (2013). Development: do mouse embryos play dice? Curr Biol. 23(1):R15-7. doi: 10.1016/j.cub.2012.10.032. PMID: 23305662. Click to see.

Pasque V, Radzisheuskaya A, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA and Silva JC. (2012). Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. J Cell Sci. 125(Pt 24):6094-104. doi: 10.1242/jcs.113019. PMID: 23077180. Click to see.

Morris SA, Guo Y and Zernicka-Goetz M. (2012). Developmental plasticity is bound by pluripotency and the Fgf and Wnt signaling pathways. Cell Rep. 2(4):756-65. doi: 10.1016/j.celrep.2012.08.029. PMID: 23041313. Click to see.

Ajduk A and Zernicka-Goetz M. (2012). Advances in embryo selection methods. F1000 Biol Rep. 4:11. doi: 10.3410/B4-11. PMID: 22685489. Click to see.

Lee YH, Ma H, Tan TZ, Ng SS, Soong R, Mori S, Fu XY, Zernicka-Goetz M and Wu Q. (2012). Protein arginine methyltransferase 6 regulates embryonic stem cell identity. Stem Cells Dev. 21(14):2613-22. doi: 10.1089/scd.2011.0330. PMID: 22455726. Click to see.

Morris SA, Grewal S, Barrios F, Patankar SN, Strauss B, Buttery L, Alexander M, Shakesheff KM and Zernicka-Goetz M. (2012). Dynamics of anterior-posterior axis formation in the developing mouse embryo. Nat Commun. 3:673. doi: 10.1038/ncomms1671. PMID: 22334076. Click to see.

Swann K, Windsor S, Campbell K, Elgmati K, Nomikos M, Zernicka-Goetz M, Amso N, Lai FA, Thomas A and Graham C. (2011). Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection. Fertil Steril. 97(3):742-7. doi: 10.1016/j.fertnstert.2011.12.013. PMID: 22217962. Click to see.

Ajduk A, Ilozue T, Windsor S, Yu Y, Seres KB, Bomphrey RJ, Tom BD, Swann K, Thomas A, Graham C and Zernicka-Goetz M. (2011). Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability. Nat Commun. 2:417. doi: 10.1038/ncomms1424. PMID: 21829179. Click to see.

Sharif B, Na J, Lykke-Hartmann K, McLaughlin SH, Laue E, Glover DM and Zernicka-Goetz M. (2010). The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes. J Cell Sci. 123(Pt 24):4292-300. doi: 10.1242/jcs.067447. PMID: 21123620. Click to see.

Zernicka-Goetz M and Huang S. (2010). Stochasticity versus determinism in development: a false dichotomy? Nat Rev Genet. 11(11):743-4. doi: 10.1038/nrg2886. PMID: 20877326. Click to see.

Parfitt DE and Zernicka-Goetz M. (2010). Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo. Mol Biol Cell. 21(15):2649-60. doi: 10.1091/mbc.E10-01-0053. PMID: 20554762. Click to see.

Jedrusik A, Bruce AW, Tan MH, Leong DE, Skamagki M, Yao M and Zernicka-Goetz M. (2010). Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo. Dev Biol. 344(1):66-78. doi: 10.1016/j.ydbio.2010.04.017. PMID: 20430022. Click to see.

Morris SA, Teo RT, Li H, Robson P, Glover DM and Zernicka-Goetz M. (2010). Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc Natl Acad Sci U S A. 107(14):6364-9. doi: 10.1073/pnas.0915063107. PMID: 20308546. Click to see.

Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford CF, Glover DM and Zernicka-Goetz M. (2009). CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation. Stem Cells. 27(11):2637-2645. doi: 10.1002/stem.131. PMID: 19544422. Click to see.

Meilhac SM, Adams RJ, Morris SA, Danckaert A, Le Garrec JF and Zernicka-Goetz M. (2009). Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst. Dev Biol. 331(2):210-21. doi: 10.1016/j.ydbio.2009.04.036. PMID: 19422818. Click to see.

Jedrusik A, Parfitt DE, Guo G, Skamagki M, Grabarek JB, Johnson MH, Robson P and Zernicka-Goetz M. (2008). Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 22(19):2692-706. doi: 10.1101/gad.486108. PMID: 18832072. Click to see.

Lykke-Andersen K, Gilchrist MJ, Grabarek JB, Das P, Miska E and Zernicka-Goetz M. (2008). Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition. Mol Biol Cell.19(10):4383-92. doi: 10.1091/mbc.e08-02-0219. PMID: 18701707. Click to see.

Soares ML, Torres-Padilla ME and Zernicka-Goetz M. (2008). Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo. Dev Growth Differ. (7):615-21. doi: 10.1111/j.1440-169X.2008.01059.x. PMID: 18657169. Click to see.

Bischoff M, Parfitt DE and Zernicka-Goetz M. (2008). Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions. Development. 135(5):953-62. doi: 10.1242/dev.014316. PMID: 18234722. Click to see.

Perea-Gomez A, Meilhac SM, Piotrowska-Nitsche K, Gray D, Collignon J and Zernicka-Goetz M. (2007). Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder. BMC Dev Biol. 7:96. doi: 10.1186/1471-213X-7-96. PMID: 17705827. Click to see.

Torres-Padilla ME, Richardson L, Kolasinska P, Meilhac SM, Luetke-Eversloh MV and Zernicka-Goetz M. (2007). The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation. Dev Biol. 309(1):97-112. doi: 10.1016/j.ydbio.2007.06.020. PMID: 17662710. Click to see.

Frankenberg S, Smith L, Greenfield A and Zernicka-Goetz M. (2007). Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. BMC Dev Biol. 7:8. doi: 10.1186/1471-213X-7-8. PMID: 17302988. Click to see.

Torres-Padilla ME, Parfitt DE, Kouzarides T and Zernicka-Goetz M. (2007). Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature. 445(7124):214-8. doi: 10.1038/nature05458. PMID: 17215844. Click to see.

Na J, Lykke-Andersen K, Torres Padilla ME and Zernicka-Goetz M. (2007). Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Dev Biol. 302(1):40-9. doi: 10.1016/j.ydbio.2006.08.036. PMID: 17005174. Click to see.

Torres-Padilla ME and Zernicka-Goetz M. (2006). Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J Cell Biol. 174(3):329-38. doi: 10.1083/jcb.200603146. PMID: 16880268. Click to see.

Na J and Zernicka-Goetz M. (2006). Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function. Curr Biol. 16(12):1249-54. doi: 10.1016/j.cub.2006.05.023. PMID: 16782018. Click to see.

Torres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T and Zernicka-Goetz M. (2006). Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos. Int J Dev Biol.50(5):455-61. doi: 10.1387/ijdb.052073mt. PMID: 16586346. Click to see.

Richardson L, Torres-Padilla ME and Zernicka-Goetz M. (2006). Regionalised signalling within the extraembryonic ectoderm regulates anterior visceral endoderm positioning in the mouse embryo. Mech Dev.123(4):288-96. doi: 10.1016/j.mod.2006.01.004. PMID: 16517131. Click to see.

Soares ML, Haraguchi S, Torres-Padilla ME, Kalmar T, Carpenter L, Bell G, Morrison A, Ring CJ, Clarke NJ, Glover DM and Zernicka-Goetz M. (2005). Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi. BMC Dev Biol. 5:28. doi: 10.1186/1471-213X-5-28. PMID: 16381610. Click to see.

Moore CA and Zernicka-Goetz M. (2005). PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles. Reproduction. 130(3):311-20. doi: 10.1530/rep.1.00651. PMID: 16123238. Click to see.

Piotrowska-Nitsche K and Zernicka-Goetz M. (2005). Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo. Mech Dev. 122(4):487-500. doi: 10.1016/j.mod.2004.11.014. PMID: 15804563. Click to see.

Plusa B, Hadjantonakis AK, Gray D, Piotrowska-Nitsche K, Jedrusik A, Papaioannou VE, Glover DM and Zernicka-Goetz M. (2005). The first cleavage of the mouse zygote predicts the blastocyst axis. Nature.434(7031):391-5. doi: 10.1038/nature03388. PMID: 15772664. Click to see.

Plusa B, Frankenberg S, Chalmers A, Hadjantonakis AK, Moore CA, Papalopulu N, Papaioannou VE, Glover DM and Zernicka-Goetz M. (2005). Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo. J Cell Sci. 118(Pt 3):505-15. doi: 10.1242/jcs.01666. PMID: 15657073. Click to see.

Piotrowska-Nitsche K, Perea-Gomez A, Haraguchi S and Zernicka-Goetz M. (2005). Four-cell stage mouse blastomeres have different developmental properties. Development. 132(3):479-90. doi: 10.1242/dev.01602. PMID: 15634695. Click to see.

Carpenter L and Zernicka-Goetz M. (2004). Directing pluripotent cell differentiation using “diced RNA” in transient transfection. Genesis. 40(3):157-63. doi: 10.1002/gene.20078. PMID: 15515021. Click to see.

Gray D, Plusa B, Piotrowska K, Na J, Tom B, Glover DM and Zernicka-Goetz M. (2004). First cleavage of the mouse embryo responds to change in egg shape at fertilization. Curr Biol. 14(5):397-405. doi: 10.1016/j.cub.2004.02.031. PMID: 15028215. Click to see.

Mesnard D, Filipe M, Belo JA and Zernicka-Goetz M. (2004). The anterior-posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation. Curr Biol.14(3):184-96. doi: 10.1016/j.cub.2004.01.026. PMID: 14761650. Click to see.

Wang QT, Piotrowska K, Ciemerych MA, Milenkovic L, Scott MP, Davis RW and Zernicka-Goetz M. (2004). A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell. 6(1):133-44. doi: 10.1016/s1534-5807(03)00404-0. PMID: 14723853. Click to see.

Zernicka-Goetz M. (2003). Determining the first cleavage of the mouse zygote. Reprod Biomed Online. 6(2):160-3. doi: 10.1016/s1472-6483(10)61704-x. PMID: 12675992. Click to see.

Durcova-Hills G, Wianny F, Merriman J, Zernicka-Goetz M and McLaren A. (2003). Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro. Differentiation. 71(2):135-41. doi: 10.1046/j.1432-0436.2003.710204.x. PMID: 12641567. Click to see.

Grabarek JB and Zernicka-Goetz M. (2003). RNA interference in mammalian systems–a practical approach. Adv Exp Med Biol. 544:205-16. doi: 10.1007/978-1-4419-9072-3_24. PMID: 14713230. Click to see.

Grabarek JB, Wianny F, Plusa B, Zernicka-Goetz M and Glover DM. (2003). RNA interference by production of short hairpin dsRNA in ES cells, their differentiated derivatives, and in somatic cell lines. Biotechniques.34(4):734-6, 739-44. doi: 10.2144/03344st02. PMID: 12703298. Click to see.

Piotrowska K and Zernicka-Goetz M. (2002). Early patterning of the mouse embryo–contributions of sperm and egg. Development. 129(24):5803-13. doi: 10.1242/dev.00170. PMID: 12421718. Click to see.

Plusa B, Grabarek JB, Piotrowska K, Glover DM and Zernicka-Goetz M. (2002). Site of the previous meiotic division defines cleavage orientation in the mouse embryo. Nat Cell Biol. 4(10):811-5. doi: 10.1038/ncb860. PMID: 12360292. Click to see.

Grabarek JB, Plusa B, Glover DM and Zernicka-Goetz M. (2002). Efficient delivery of dsRNA into zona-enclosed mouse oocytes and preimplantation embryos by electroporation. Genesis. 32(4):269-76. doi: 10.1002/gene.10076. PMID: 11948914. Click to see.

Plusa B, Piotrowska K and Zernicka-Goetz M. (2002). Sperm entry position provides a surface marker for the first cleavage plane of the mouse zygote. Genesis. 32(3):193-8. doi: 10.1002/gene.10027. PMID: 11892007. Click to see.

Frankenberg S and Zernicka-Goetz M. (2004). Breaking radial symmetry: amniote type. Gastrulation: from cells to embryo. 

Piotrowska K, Wianny F, Pedersen RA and Zernicka-Goetz M. (2001). Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development. Development. 128(19):3739-48. PMID: 11585800. Click to see.

Piotrowska K and Zernicka-Goetz M. (2001). Role for sperm in spatial patterning of the early mouse embryo. Nature. 409(6819):517-21. doi: 10.1038/35054069. PMID: 11206548. Click to see.

Zernicka-Goetz M and Pines J. (2001). Use of Green Fluorescent Protein in mouse embryos. Methods.24(1):55-60. doi: 10.1006/meth.2001.1157. PMID: 11327803. Click to see.

Ciemerych MA, Mesnard D and Zernicka-Goetz M. (2000). Animal and vegetal poles of the mouse egg predict the polarity of the embryonic axis, yet are nonessential for development. Development. 127(16):3467-74. PMID: 10903172. Click to see.

Wianny F and Zernicka-Goetz M. (2000). Specific interference with gene function by double-stranded RNA in early mouse development. Nat Cell Biol. 2(2):70-5. doi: 10.1038/35000016. PMID: 10655585. Click to see.

Grabarek J and Zernicka-Goetz M. (2000). Progression of mouse oocytes from metaphase I to metaphase II is inhibited by fusion with G2 cells. Zygote. 8(2):145-51. doi: 10.1017/s0967199400000927. PMID: 10857585. Click to see.

Zernicka-Goetz M and Pines J. (2000). Cell lineage analysis. Applications of green fluorescent protein. Methods Mol Biol. 135:279-87. doi: 10.1385/1-59259-685-1:279. PMID: 10791324. Click to see.

Weber RJ, Pedersen RA, Wianny F, Evans MJ and Zernicka-Goetz M. (1999). Polarity of the mouse embryo is anticipated before implantation. Development. 126(24):5591-8. PMID: 10572036. Click to see.

Zernicka-Goetz M. (1999). Green Fluorescent Protein: a new approach to understanding spatial patterning and cell fate in early mammalian development. In Cell Lineage and Fate Determination. 521-527. https://doi.org/10.1016/B978-012505255-9/50036-5. Click to see.

Zernicka-Goetz M. (1998). Fertile offspring derived from mammalian eggs lacking either animal or vegetal poles. Development. 125(23):4803-8. PMID: 9806928. Click to see.

Wianny F, Tavares A, Evans MJ, Glover DM and Zernicka-Goetz M. (1998). Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation. Chromosoma. 107(6-7):430-9. doi: 10.1007/s004120050327. PMID: 9914375. Click to see.

Zernicka-Goetz M, Pines J, McLean Hunter S, Dixon JP, Siemering KR, Haseloff J and Evans MJ. (1997). Following cell fate in the living mouse embryo. Development. 124(6):1133-7. doi: 10.1007/s004120050327. PMID: 9102300. Click to see.

Zernicka-Goetz M, Verlhac MH, Géraud G and Kubiak JZ. (1997). Protein phosphatases control MAP kinase activation and microtubule organization during rat oocyte maturation. Eur J Cell Biol. 72(1):30-8. PMID: 9013723. Click to see.

Zernicka-Goetz M, Pines J, Ryan K, Siemering K, Haseloff J, Evans M.J, and Gurdon J. (1996). An indelible lineage marker for Xenopus using a mutated green fluorescent protein. Development. 122(12):3719-24.PMID: 901249. Click to see.

Zernicka-Goetz M, Ciemerych A.M, Kubiak J.Z, Tarkowski A.K. and Maro B. (1995). Cytostatic factor inactivation is induced by a calcium-dependent mechanism present until the second cell cycle in fertilized but not in parthenogenetically activated mouse eggs. J Cell Sci. 108 (Pt 2):469-74. PMID: 7768994. Click to see.

Zernicka-Goetz M. (1994). Activation of embryonic genes during preimplantation rat development. Mol Reprod Dev. 38(1):30-5. doi: 10.1002/mrd.1080380106. PMID: 8049062. Click to see.

Zernicka-Goetz M, Weber M and Maro B. (1993). Full activation of the rat oocyte by protein synthesis inhibition requires protein phosphatase activity. Int J Dev Biol. 37(2):273-7. PMID: 8398674. Click to see.

Zernicka-Goetz M and Maro B. (1993). Okadaic acid affects spindle organization in metaphase II-arrested rat oocytes. Exp Cell Res. 207(1):189-93. doi: 10.1006/excr.1993.1179. PMID: 8391463. Click to see.

Zernicka-Goetz M, Kubiak JZ, Antony C, and Maro B. (1993). Cytoskeletal organization of rat oocytes during metaphase II arrest and following abortive activation: a study by confocal laser scanning microscopy. Mol Reprod Dev. 35(2):165-75. doi: 10.1002/mrd.1080350210. PMID: 8100426. Click to see.

Zernicka-Goetz M. (1991). Spontaneous and induced activation of rat oocytes. Mol Reprod Dev. 28(2):169-76. doi: 10.1002/mrd.1080280210. PMID: 2007030. Click to see.

Books and Reviews

Zernicka-Goetz M and Roger Highfield. The Dance of Life. (2020). Penguin Random House (UK) and The Basic Books (USA). Click to see BioReview.

Zhu M and Zernicka-Goetz M. (2020). Principles of Self-Organization of the Mammalian Embryo. Cell.183(6):1467-1478. doi: 10.1016/j.cell.2020.11.003. PMID: 33306953. Click to see.

Molè MA, Weberling A and Zernicka-Goetz M. (2020). Comparative analysis of human and mouse development: From zygote to pre-gastrulation. Curr Top Dev Biol. 136:113-138. doi: 10.1016/bs.ctdb.2019.10.002. PMID: 31959285. Click to see.

Zhu M and Zernicka-Goetz M. (2020). Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives. Curr Opin Cell Biol. 62:144-149. doi: 10.1016/j.ceb.2019.11.005. PMID: 31869760. Click to see.

Shahbazi MN and Zernicka-Goetz M. (2018). Deconstructing and reconstructing the mouse and human early embryo. Nat Cell Biol. 20(8):878-887. doi: 10.1038/s41556-018-0144-x. PMID: 30038253. Click to see.

Chen Q, Shi J, Tao Y and Zernicka-Goetz M. (2018). Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo. Nat Commun. 9(1):1819. doi: 10.1038/s41467-018-04155-2. PMID: 29739935. Click to see.

Graham SJ and Zernicka-Goetz M. (2016). The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous? Curr Top Dev Biol. 117:671-95. doi: 10.1016/bs.ctdb.2015.11.021. PMID: 26970007. Click to see.

Leung CY and Zernicka-Goetz M. (2015). Mapping the journey from totipotency to lineage specification in the mouse embryo. Curr Opin Genet Dev. 34:71-6. doi: 10.1016/j.gde.2015.08.002. PMID: 26343010. Click to see.

Bedzhov I, Graham SJ, Leung CY and Zernicka-Goetz M. (2014). Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo. Philos Trans R Soc Lond B Biol Sci.369(1657):20130538. doi: 10.1098/rstb.2013.0538. PMID: 25349447. Click to see.

Ajduk A and Zernicka-Goetz M. (2013). Quality control of embryo development. Mol Aspects Med. 34(5):903-18. doi: 10.1016/j.mam.2013.03.001. PMID: 23563243. Click to see.

Morris SA and Zernicka-Goetz M. (2012). Formation of distinct cell types in the mouse blastocyst. Results Probl Cell Differ. 55:203-17. doi: 10.1007/978-3-642-30406-4_11. PMID: 22918808. Click to see.

Bruce AW and Zernicka-Goetz M. (2010). Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate. Curr Opin Genet Dev. 20(5):485-91. doi: 10.1016/j.gde.2010.05.006. PMID: 20554442. Click to see.

Zernicka-Goetz M, Morris SA and Bruce AW. (2009). Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo. Nat Rev Genet. 10(7):467-77. doi: 10.1038/nrg2564. PMID: 19536196. Click to see.

Zernicka-Goetz M. (2006). The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice. Curr Opin Genet Dev. 16(4):406-12. doi: 10.1016/j.gde.2006.06.011. PMID: 16806896. Click to see.

Zernicka-Goetz M. (2004). First cell fate decisions and spatial patterning in the early mouse embryo. Semin Cell Dev Biol. 15(5):563-72. doi: 10.1016/j.semcdb.2004.04.004. PMID: 15271302. Click to see.

Grabarek JB and Zernicka-Goetz M. (2003). RNA interference in mammalian systems-a practical approach. Adv Exp Med Biol. 544:205-16. doi: 10.1007/978-1-4419-9072-3_24. PMID: 14713230. Click to see.

Zernicka-Goetz M. (2002). Patterning of the embryo: the first spatial decisions in the life of a mouse. Development. 129(4):815-29. PMID: 11861466. Click to see.

Zernicka-Goetz M. (2000). Life is in the bag, or is it? Book review “The Spark of Life: Darwin and the Primeval Soup” Nature Cell Biology. 10, 189.

Other publications

Hurlbut JB, Hyun I, Levine AD, Lovell-Badge R, Lunshof JE, Matthews KRW, Mills P, Murdoch A, Pera MF, Scott CT, Tizzard J, Warnock M, Zernicka-Goetz M, Zhou Q and Zoloth L. (2017). Revisiting the Warnock rule. Nat Biotechnol. 35(11):1029-1042. doi: 10.1038/nbt.4015. PMID: 29121021. Click to see.

Zernicka-Goetz M. (2016). Andrzej K. Tarkowski 1933-2016. Nat Cell Biol. 18(12):1261. doi: 10.1038/ncb3446. PMID: 27897160. Click to see.

Rosenthal N and Zernicka-Goetz M. (2014). A tribute to Sir John Gurdon. Differentiation. 88(1):1-2. doi: 10.1016/j.diff.2014.11.001. PMID: 25455201. Click to see.

Zernicka-Goetz M and Hadjantonakis AK. (2014). From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo. Philos Trans R Soc Lond B Biol Sci. 369(1657). doi: 10.1098/rstb.2013.0535. PMID: 25349444. Click to see.

Duan EK, Wang H and Zernicka-Goetz M. (2013). Introduction to the special issue “Molecular Players in Early Pregnancy”. Mol Aspects Med. 34(5):vi-vii. doi: 10.1016/S0098-2997(13)00054-X. PMID: 23910666. Click to see.

Zernicka-Goetz M. (2011). Proclaiming fate in the early mouse embryo. Nat Cell Biol. 13(2):112-4. doi: 10.1038/ncb0211-112. PMID: 21283119. Click to see.

Adjaye JA, Byskov AG, Cibelli JB, De Maria R, Minger S, Sampaolesi M, Testa G, Verfaillie C, Zernicka-Goetz M, Schöler H, Boiani M, Crosetto N and Redi CA. (2008). Pluripotency and differentiation in embryos and stem cells. Int J Dev Biol. 52(7):801-9. doi: 10.1387/ijdb.082695ja. PMID: 18956312. Click to see.

Firtel R and Zernicka-Goetz M. (2006). Pattern formation and developmental mechanisms. Editorial overview. Curr Opin Gene and Dev. 16, 331-332. Click to see.

Zernicka-Goetz M. (2004). Introduction. Seminars in Cell & Dev Biol. 15(5), 541.

Zernicka-Goetz M. (2000). Transplantation that should not be rejected. The Parliamentary MonitorLondon.8: 22. 

Zernicka-Goetz M. (2000). Jumping the gun on mouse gene expression. Correspondence to Nature. 405, 733.

Wianny F and Zernicka-Goetz M. (2000). RNA interference: application to eliminate gene expression in mammals. Medecine/Sciences. 16: 993-995.

Zernicka-Goetz M. (2005). Cleavage pattern and emerging asymmetry of the mouse embryo. Nat Rev Mol Cell Biol. 6(12):919-28. doi: 10.1038/nrm1782. PMID: 16341078. Click to see.